A Burkitt s-like B-cell lymphoma (BLL) has recently been shown to be associated with the acquired immunodeficiency syndrome (AIDS), which affects homosexual men. We report cytogenetic studies of two BLL tumors in homosexual men. Both tumors had chromosome translocations characteristic of Burkitt s lymphoma (BL), one t
Cryptosporidiosis, a zoonosis caused by Cryptosporidium species, is a newly recognized coccidial protozoan infection causing severe protracted watery diarrhea in humans. In August 1981, the first case of cryptosporidiosis in a homosexual man with acquired immune deficiency syndrome (AIDS) was reported; diagnosis was d
N Engl J Med. 1983 May 26;308(21):1252-7. Unique Identifier : AIDSLINE MED/83192324
Current WL; Reese NC; Ernst JV; Bailey WS; Heyman MB; Weinstein WM
Infection with cryptosporidium occurred in 12 immunocompetent persons who had direct contact with the feces of infected calves during three unrelated outbreaks of calf cryptosporidiosis. Nine of the twelve subjects had diarrhea and abdominal cramps that lasted 1 to 10 days. Infections were diagnosed and monitored by d
N Engl J Med. 1983 Jun 9;308(23):1419-20. Unique Identifier : AIDSLINE MED/83192378
Boncy M; Laroche AC; Liautaud B; Mathurin JR; Pape JW; Pamphile M; Pean V; St-Amand MM; Thomas F; Arnoux E; Elie R; Guerin JM; Laroche AC; Malebranche R; Pierre G
Begin R; Cantin A; Drapeau G; Lamoureux G; Boctor M; Masse S; Rola-Pleszczynski M
To evaluate the 67Ga lung uptake as an indicator of inflammatory activity in asbestosis, we obtained 67Ga lung scans in 58 long-term asbestos workers. The 67Ga localized excessively in the lungs of 17 of the 21 workers with asbestosis. Among workers without sufficient criteria for the diagnosis of asbestosis, the 67Ga
The acquired immune deficiency syndrome (AIDS) is characterized by T-lymphocyte dysfunction and is frequently accompanied by opportunistic infections and Kaposi s sarcoma. Human T-cell leukemia virus (HTLV) is associated with T-cell malignancies and can transform T lymphocytes in vitro. In an attempt to find evidence
Science. 1983 May 20;220(4599):865-7. Unique Identifier : AIDSLINE MED/83197367
Gallo RC; Sarin PS; Gelmann EP; Robert-Guroff M; Richardson E; Kalyanaraman VS; Mann D; Sidhu GD; Stahl RE; Zolla-Pazner S; Leibowitch J; Popovic M
Several isolates of a human type-C retrovirus belonging to one group, known as human T-cell leukemia virus (HTLV), have previously been obtained from patients with adult T-cell leukemia or lymphoma. The T-cell tropism of HTLV and its prevalence in the Caribbean basin prompted a search for it in patients with the epide
Bacterial pneumonia remains a serious infectious disease even in the modern era of antibiotics and still causes significant morbidity and mortality. Because of the large number of organisms that may cause pulmonary disease, the inexactness of commonly used diagnostic techniques, and the serious consequences of untreat
Science. 1983 May 20;220(4599):859-62. Unique Identifier : AIDSLINE MED/83197365
Essex M; McLane MF; Lee TH; Falk L; Howe CW; Mullins JI; Cabradilla C; Francis DP
The acquired immune deficiency syndrome (AIDS), which has recently occurred at increasing rates in homosexual men, intravenous drug users, and others, is characterized by the development of Kaposi s sarcoma and several opportunistic infections including pneumonia caused by Pneumocystis carinii. Serum samples from pati
A retrovirus belonging to the family of recently discovered human T-cell leukemia viruses (HTLV), but clearly distinct from each previous isolate, has been isolated from a Caucasian patient with signs and symptoms that often precede the acquired immune deficiency syndrome (AIDS). This virus is a typical type-C RNA tum
N Engl J Med. 1983 May 19;308(20):1181-4. Unique Identifier : AIDSLINE MED/83192302
Harris C; Small CB; Klein RS; Friedland GH; Moll B; Emeson EE; Spigland I; Steigbigel NH
Because the current outbreak of acquired immunodeficiency syndrome (AIDS) among previously healthy adults may be caused by a transmissible biologic agent, and because it may be preceded by immunologic abnormalities with or without a prodromal illness, we studied seven female sexual partners of male patients with the s
Two young homosexual men apparently without any obvious cause of immunosuppression suddenly developed a series of opportunistic infections. Two others presented with prolonged fever and multiple lymph node enlargement of obscure origin. Immunological investigations in these 4 patients showed skin anergy and inversion
A naturally occurring immunodeficiency syndrome has been seen in a captive colony of macaque monkeys. This syndrome is seen primarily in the species Macaca cyclopis. Affected animals died with lymphomas (a rare disease in macaques) or such opportunistic infections as Pneumocystis carinii and noma (necrotizing gingivit
We have identified the oncogene and the putative transforming protein of the Parodi-Irgens feline sarcoma virus (PI-FeSV). The PI-FeSV is defective and needs a helper virus for its replication. The v-onc sequences in the PI-FeSV were found to be related to the v-sis sequences of the simian sarcoma virus (SSV). PI-FeSV
We studied viral injury to the kidney in a six-year-old boy with hyperimmunoglobulin M immunodeficiency who presented with irreversible acute renal failure and eventually died after five months of dialysis. Renal biopsy at the time of his presentation revealed a predominantly tubulo-interstitial process with numerous
NIPH Ann. 1982 Dec;5(2):41-9. Unique Identifier : AIDSLINE MED/83193064
Strand OA
The acquired immunodeficiency syndrome (AIDS) is a new, serious condition of major public health concern. It is most prevalent among young homosexuals and may be present with Kaposi s sarcoma and serious opportunistic infections. Physicians dealing with male homosexuals should be aware of this diagnostic possibility i
There is considerable current interest in the agents that cause the spongiform encephalopathies: scrapie, transmissible mink encephalopathy, kuru, and Creutzfeldt-Jakob disease (CJD). The unusual properties of these agents, their elusiveness, and their pathogenicity for humans (in the cases of kuru and CJD) make these
There is a continuing controversy about the quality of unaided clinical judgment. This paper reports two studies that show that experienced medical providers made accurate probability assessments and applied those assessments to patient care in a manner consistent with principles of optimal decision making. In the fir
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