[LEUKOCYTE MIGRATION INHIBITION INDUCED BY EPSTEIN-BARR VIRUS ANTIGENS. IMMUNITY IN INFECTIOUS MONONUCLEOSIS AND SOME IMMUNODEFICIENT AND IMMUNOSUPPRESSED STATES]

Important note: Information in this article was accurate in 1982. The state of the art may have changed since the publication date.

[LEUKOCYTE MIGRATION INHIBITION INDUCED BY EPSTEIN-BARR VIRUS ANTIGENS. IMMUNITY IN INFECTIOUS MONONUCLEOSIS AND SOME IMMUNODEFICIENT AND IMMUNOSUPPRESSED STATES]

Orv Hetil; 123(20):1217-1221 1982. Unique Identifier : AIDSLINE ICDB/82623140
Szigeti R; Klein E; Masucci MG; Ernberg I; Svedmyr E; Klein G; II. Gyermekklinika, Semmelweis Orvostudomany Egyetem, Budapest,; Hungary

Abstract: Leukocyte migration inhibition (LMI) elicited by Epstein-Barr virus (EBV) antigens was studied in 13 patients with infectious mononucleosis (IM), 2 patients with chronic mononucleosis, 4 with sex-linked lymphoproliferative disease and in 12 patients with neoplastic diseases (5 with Hodgkin's disease, 6 with non-Hodgkin's lymphoma and 1 with chronic lymphocytic leukemia). Appreciable LMI was observed in the patients with IM in response to enriched early antigen-virus capsid antigen (EA/VCA) extracts. Similar LMI of mononucleosis type (sensitivity to EA/VCA and insensitivity to EBV nuclear antigen (NA)) was seen in chronic mononucleosis as well, while the patients with sex-linked lymphoproliferative disease failed to respond to any EBV antigens. Tumor patients with elevated EBV antibody titers either showed LMI similar to that seen in healthy, seropositive controls or LMI of the mononucleosis type. The findings suggest that an intact immune system is necessary for LMI to occur in response to EBVNA or to crude cellular extracts containing mainly EBVNA, while sensitivity to EA/VCA is present when the immune system is impaired to a certain extent. Late hypersensitivity reaction in vitro is absent in severe immunodeficiency or immunosuppression. (42 Refs)

Keywords: Adolescence Adult Aged Antigens, Viral/*IMMUNOLOGY *Cell Migration Inhibition Child Female Herpesvirus 4, Human/*IMMUNOLOGY Hodgkin's Disease/IMMUNOLOGY Human Immune Tolerance Infectious Mononucleosis/*IMMUNOLOGY/MICROBIOLOGY Leukocytes/*IMMUNOLOGY Lymphoma/IMMUNOLOGY Male Middle Age JOURNAL ARTICLE

821030
M82A0024

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