Severe acquired immunodeficiency in European homosexual men. NLM AIDSLINE Important note: Information in this article was accurate in 1982. The state of the art may have changed since the publication date.

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Severe acquired immunodeficiency in European homosexual men.

Br Med J (Clin Res Ed). 1982 Jul 3;285(6334):17-9. Unique Identifier : AIDSLINE MED/82207649
Gerstoft J; Malchow-Moller A; Bygbjerg I; Dickmeiss E; Enk C; Halberg P; Haahr S; Jacobsen M; Jensen K; Mejer J; Nielsen JO; Thomsen HK; Sondergaard J; Lorenzen I

Abstract: Four previously healthy Danish homosexual men developed Kaposi's sarcoma or opportunistic infections with fever of unknown origin and lymphadenopathy. One patient died of a Pneumocystis carinii pneumonia. Three patients had defective cell-mediated immunity with absent leucocyte interferon production and decreased proliferative response to mitogens and antigens. T lymphocyte helper subsets and natural killer cell activity were reduced. Unstimulated mononuclear cells produced leucocyte migration inhibitor factor. Two patients were sexual partners and three had never been to the USA, where cases of severe acquired immunodeficiency have been reported. Thus, the syndrome must also be suspected in European homosexual men who present with fever of unknown origin, opportunistic infections, or Kaposi's sarcoma.
Keywords: Adult Case Report Denmark *Homosexuality Human Immunity, Cellular Immunologic Deficiency Syndromes/COMPLICATIONS/*ETIOLOGY/ IMMUNOLOGY Male Middle Age Pneumonia, Pneumocystis carinii/ETIOLOGY Sarcoma, Kaposi's/ETIOLOGY JOURNAL ARTICLE

KWDadultcasereportdenmarkKWDhomosexualityhumanimmunity,cellularimmunologicdeficiencysyndromes/complications/KWDetiology/immunologymalemiddleagepneumonia,pneumocystiscarinii/etiologysarcoma,kaposi's/etiologyjournalarticle
821030
M82A0015

Copyright © 1982 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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