Disseminated Kaposi's sarcoma in homosexual men. NLM AIDSLINE Important note: Information in this article was accurate in 1982. The state of the art may have changed since the publication date.

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Disseminated Kaposi's sarcoma in homosexual men.

Ann Intern Med. 1982 Jun;96(6 Pt 1):693-700. Unique Identifier : AIDSLINE MED/82229061
Friedman-Kien AE; Laubenstein LJ; Rubinstein P; Buimovici-Klein E; Marmor M; Stahl R; Spigland I; Kim KS; Zolla-Pazner S

Abstract: Nineteen cases from an epidemic of disseminated Kaposi's sarcoma in homosexual men were studied by clinical, virologic, immunologic, and genetic methods. The patients were all male homosexuals ranging in age from 29 to 52 years, with histories of multiple sexually transmitted diseases and exposure to both prescription and recreational drugs. Sites of disease included skin (16 of 19 patients), lymph nodes (13 patients), gastrointestinal tract (12 patients), spleen (three patients), and lung (one patient). Most patients had elevated levels of serum immunoglobins, positive antibody titers to hepatitis A and B virus, cytomegalovirus and Epstein-Barr virus, and impairment of cell-mediated immunologic reactions. The frequency of HLA-DR5 in these patients was significantly elevated. Two of the 19 patients died. Although the precise cause of this epidemic is unknown, it is likely that a genetic predisposition, an acquired immunoregulatory defect, and one or more infectious agents and drugs may be involved.
Keywords: Adult Cytomegalovirus Infections/IMMUNOLOGY Gastrointestinal System/PATHOLOGY Histocompatibility Antigens Class II/IMMUNOLOGY *Homosexuality Human Immunity, Cellular Lymph Nodes/PATHOLOGY Male Middle Age Pneumonia, Pneumocystis carinii/COMPLICATIONS Sarcoma, Kaposi's/COMPLICATIONS/IMMUNOLOGY/*PATHOLOGY Sexually Transmitted Diseases/IMMUNOLOGY/PATHOLOGY Skin/PATHOLOGY Skin Neoplasms/COMPLICATIONS/IMMUNOLOGY/*PATHOLOGY Substance Abuse/COMPLICATIONS Support, Non-U.S. Gov't Support, U.S. Gov't, Non-P.H.S. Support, U.S. Gov't, P.H.S. JOURNAL ARTICLE

KWDadultcytomegalovirusinfections/immunologygastrointestinalsystem/pathologyhistocompatibilityantigensclassii/immunologyKWDhomosexualityhumanimmunity,cellularlymphnodes/pathologymalemiddleagepneumonia,pneumocystiscarinii/complicationssarcoma,kaposi's/complications/immunology/KWDpathologysexuallytransmitteddiseases/immunology/pathologyskin/pathologyskinneoplasms/complications/immunology/KWDpathologysubstanceabuse/complicationssupport,non-uKWDsKWDgov'tsupport,uKWDsKWDgov't,non-pKWDhKWDsKWDsupport,uKWDsKWDgov't,pKWDhKWDsKWDjournalarticle
821030
M82A0008

Copyright © 1982 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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