Cytomegalovirus and Kaposi's sarcoma in young homosexual men. NLM AIDSLINE Important note: Information in this article was accurate in 1982. The state of the art may have changed since the publication date.

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Cytomegalovirus and Kaposi's sarcoma in young homosexual men.

Lancet. 1982 Jul 17;2(8290):125-7. Unique Identifier : AIDSLINE MED/82218751
Drew WL; Conant MA; Miner RC; Huang ES; Ziegler JL; Groundwater JR; Gullett JH; Volberding P; Abrams DI; Mintz L

Abstract: 10 homosexual men with Kaposi's sarcoma (KS) were studied for evidence of cytomegalovirus (CMV) infection. IgG and IgM antibodies to CMV were detected in 9 out of 9 and in 7 out of 9 of these patients, respectively. CMV was recovered from body secretions or peripheral blood of 7 patients. Viral cultures of KS tumour biopsy specimens were negative in 8 out of 8 patients, but CMV RNA was detected by in-situ hybridisation in 2 out of 3 and CMV antigen(s) by immunofluorescence in 6 out of 9. Normal tissue specimens from 3 KS patients were negative for CMV antigen. These observations suggest an association of CMV with KS.
Keywords: Adult Animal Antibodies, Viral/ANALYSIS Cytomegalovirus/*IMMUNOLOGY/ISOLATION & PURIF Cytomegalovirus Infections/*COMPLICATIONS *Homosexuality Human IgG/ANALYSIS IgM/ANALYSIS Male Middle Age RNA, Viral/ANALYSIS Sarcoma, Kaposi's/*ETIOLOGY/IMMUNOLOGY Support, Non-U.S. Gov't Tumor Virus Infections/IMMUNOLOGY JOURNAL ARTICLE

KWDadultanimalantibodies,viral/analysiscytomegalovirus/KWDimmunology/isolation&purifcytomegalovirusinfections/KWDcomplicationsKWDhomosexualityhumanigg/analysisigm/analysismalemiddleagerna,viral/analysissarcoma,kaposi's/KWDetiology/immunologysupport,non-uKWDsKWDgov'ttumorvirusinfections/immunologyjournalarticle
821030
M82A0001

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