Nucleotide sequence analysis of the long terminal repeat of integrated simian sarcoma virus: evolutionary relationship with other mammalian retroviral long terminal repeats. NLM AIDSLINE Important note: Information in this article was accurate in 1982. The state of the art may have changed since the publication date.

Click here to return to AIDSLINE main menu
DonateNow
Print this Article


Nucleotide sequence analysis of the long terminal repeat of integrated simian sarcoma virus: evolutionary relationship with other mammalian retroviral long terminal repeats.

J Virol. 1982 Jun;42(3):1108-13. Unique Identifier : AIDSLINE GENBANK/J02397
Devare SG; Reddy EP; Law JD; Aaronson SA

Abstract: Nucleotide sequence analysis of the long terminal repeat (LTR) of the integrated simian sarcoma virus showed that the simian sarcoma virus LTR comprised 504 nucleotides with an inverted repeat of seven bases at its 5' and 3' termini. At the site of simian sarcoma virus integration, cellular flanking sequences adjacent to the proviral LTR contained a direct repeat of four bases. A 13-base sequence after the 5' LTR was found to be complementary to prolyl tRNA, suggesting that tRNAPro may serve as the primer for reverse transcription of simian sarcoma virus RNA. The U5 and R regions, derived respectively from the 5' end and terminally redundant sequences of the viral RNA, were found to have similar organization and sequence homology close to that of Moloney murine sarcoma virus or Moloney murine leukemia virus. These results indicate that regions within LTRs with known functionally important sequences have been most well conserved during retrovirus evolution.
Keywords: Comparative Study *DNA, Viral/BIOSYNTHESIS Evolution Genes, Viral Moloney Leukemia Virus/GENETICS *Recombination, Genetic *Repetitive Sequences, Nucleic Acid Retroviridae/*GENETICS RNA, Transfer RNA, Viral/BIOSYNTHESIS Sarcoma Viruses, Murine/GENETICS Sarcoma Viruses, Simian/*GENETICS Transcription, Genetic JOURNAL ARTICLE

KWDcomparativestudyKWDdna,viral/biosynthesisevolutiongenes,viralmoloneyleukemiavirus/geneticsKWDrecombination,geneticKWDrepetitivesequences,nucleicacidretroviridae/KWDgeneticsrna,transferrna,viral/biosynthesissarcomaviruses,murine/geneticssarcomaviruses,simian/KWDgeneticstranscription,geneticjournalarticle
821130
M82B0006

Copyright © 1982 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

AEGiS is a 501(c)3, not-for-profit, tax-exempt, educational corporation. AEGiS is made possible through unrestricted funding from Boehringer Ingelheim, Bridgestone/Firestone Charitable Trust, Bristol-Myers Squibb Company, Elton John AIDS Foundation, Gill Foundation, the National Library of Medicine, Quest Diagnostics, Roche and Trimeris, and donations from users like you. Always watch for outdated information. This article first appeared in 1982. This material is designed to support, not replace, the relationship that exists between you and your doctor.

AEGiS presents published material, reprinted with permission and neither endorses nor opposes any material. All information contained on this website, including information relating to health conditions, products, and treatments, is for informational purposes only. It is often presented in summary or aggregate form. It is not meant to be a substitute for the advice provided by your own physician or other medical professionals. Always discuss treatment options with a doctor who specializes in treating HIV.

Copyright ©1980, 1982. AEGiS. All materials appearing on AEGiS are protected by copyright as a collective work or compilation under U.S. copyright and other laws and are the property of AEGiS, or the party credited as the provider of the content. .