Treatment of life-threatening Epstein-Barr virus infection with acyclovir. NLM AIDSLINE Important note: Information in this article was accurate in 1982. The state of the art may have changed since the publication date.

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Treatment of life-threatening Epstein-Barr virus infection with acyclovir.

Am J Med. 1982 Jul 20;73(1A):262-6. Unique Identifier : AIDSLINE MED/82253939
Sullivan JL; Byron KS; Brewster FE; Sakamoto K; Shaw JE; Pagano JS

Abstract: Two pediatric patients with life-threatening Epstein-Barr virus infections were studied immunologically and treated with acyclovir [9-(2-hydroxyethoxymethyl) guanine]. The patient with chronic active Epstein-Barr virus infection who experienced massive hepatosplenomegaly, pancytopenia, and failure to thrive demonstrated abnormalities of T and B lymphocytes. A second patient, with the X-linked lymphoproliferative syndrome, experienced a rapidly fatal course of acute Epstein-Barr virus infection which typifies this yet undefined immunodeficiency to Epstein-Barr virus. In each case, objective evidence for clinical improvement or antiviral effect of acyclovir treatment was not apparent. Abnormally productive Epstein-Barr virus infections did not appear to play a major role in the clinical syndromes observed. Current studies are focused on treatment of immunologically normal patients with early complicated Epstein-Barr virus infection.
Keywords: Antiviral Agents/*THERAPEUTIC USE B-Lymphocytes/IMMUNOLOGY Case Report Child, Preschool Drug Evaluation Female Guanine/*ANALOGS & DERIVATIVES/THERAPEUTIC USE Herpesviridae Infections/COMPLICATIONS/*DRUG THERAPY Herpesvirus 4, Human Human Infant Lymphoproliferative Disorders/*COMPLICATIONS Male Support, Non-U.S. Gov't Support, U.S. Gov't, P.H.S. T-Lymphocytes/IMMUNOLOGY JOURNAL ARTICLE

KWDantiviralagents/KWDtherapeuticuseb-lymphocytes/immunologycasereportchild,preschooldrugevaluationfemaleguanine/KWDanalogs&derivatives/therapeuticuseherpesviridaeinfections/complications/KWDdrugtherapyherpesvirus4,humanhumaninfantlymphoproliferativedisorders/KWDcomplicationsmalesupport,non-uKWDsKWDgov'tsupport,uKWDsKWDgov't,pKWDhKWDsKWDt-lymphocytes/immunologyjournalarticle
821130
M82B0002

Copyright © 1982 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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