GENETIC MAPPING OF ECOTROPIC MURINE LEUKEMIA VIRUS-INDUCING LOCI IN SIX INBRED STRAINS NLM AIDSLINE Important note: Information in this article was accurate in 1982. The state of the art may have changed since the publication date.

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GENETIC MAPPING OF ECOTROPIC MURINE LEUKEMIA VIRUS-INDUCING LOCI IN SIX INBRED STRAINS

J Exp Med; 155(2):524-534 1982. Unique Identifier : AIDSLINE ICDB/82607206
Kozak CA; Rowe WP; Lab. Viral Diseases, Natl. Inst. Allergy and Infectious Diseases,; NIH, Bethesda, MD, 20205

Abstract: Mendelian segregation analysis was used to map chromosomal genes for the induction of endogenous N- and B-tropic ecotropic retroviruses (V loci) in high and low leukemic mouse strains. Segregation analysis resulted in the genetic mapping of V loci in six inbred strains to five mouse chromosomes. The V locus of A/J was mapped to chromosome 5 and shown to be allelic with that of BALB/cJ and C3H/HeJ (Cv); this suggests that Cv represents a stable ancestral V locus present in Bagg albino stocks before separation of inbred lines. The single, poorly inducible V locus of C57BL/10J and one of the four high virus loci of C58/Lw were mapped to the same region of chromosome 8 and may present an allelic pair with different patterns of expression. An N-tropic V locus of the SEA/GnJ mouse was mapped to chromosome 9, and one of the three V loci of C3H/FgLw was mapped to chromosome 7. The endogenous B-tropic virus of B10.BR/SgLi was mapped to chromosome 11. Several of the endogenous proviral sequences appear to be closely linked with cellular genes involved with sensitivity or resistance to retroviral infection or affecting lymphoid differentiation. Identification and separation of individual V loci aids in their characterization and makes it possible to identify DNA fragments carrying biologically defined proviruses. (26 Refs)
Keywords: Alleles Animal *Chromosome Mapping *Genes, Viral Leukemia Viruses, Murine/*GENETICS Mice Mice, Inbred Strains/GENETICS/*MICROBIOLOGY JOURNAL ARTICLE

KWDallelesanimalKWDchromosomemappingKWDgenes,viralleukemiaviruses,murine/KWDgeneticsmicemice,inbredstrains/genetics/KWDmicrobiologyjournalarticle
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Copyright © 1982 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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