Severe acquired immunodeficiency in male homosexuals, manifested by chronic perianal ulcerative herpes simplex lesions. NLM AIDSLINE Important note: Information in this article was accurate in 1982. The state of the art may have changed since the publication date.

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Severe acquired immunodeficiency in male homosexuals, manifested by chronic perianal ulcerative herpes simplex lesions.

N Engl J Med. 1981 Dec 10;305(24):1439-44. Unique Identifier : AIDSLINE MED/82057987
Siegal FP; Lopez C; Hammer GS; Brown AE; Kornfeld SJ; Gold J; Hassett J; Hirschman SZ; Cunningham-Rundles C; Adelsberg BR; et al

Abstract: Four homosexual men presented with gradually enlarging perianal ulcers, from which herpes simplex virus was cultured. Each patient had a prolonged course characterized by eight loss, fever, and evidence of infection by other opportunistic microorganisms including cytomegalovirus, Pneumocystis carinii, and Candida albicans. Three patients died; Kaposi's sarcoma developed in the fourth. All were found to have depressed cell-mediated immunity, as evidenced by skin anergy, lymphopenia, and poor or absent responses to plant lectins and antigens in vitro. Natural-killer-cell activity directed against target cells infected with herpes simplex virus was depressed in all patients. The absence of a history of recurrent infections or of histologic evidence of lymphoproliferative or other neoplastic diseases suggests that the immune defects were acquired.
Keywords: Adult Anus Diseases/*ETIOLOGY Candidiasis/COMPLICATIONS Case Report Chronic Disease Cytomegalovirus Infections/COMPLICATIONS Herpes Simplex/*ETIOLOGY/IMMUNOLOGY *Homosexuality Human *Immunity, Cellular Immunologic Deficiency Syndromes/*ETIOLOGY Killer Cells/IMMUNOLOGY Male Pneumonia, Pneumocystis carinii/COMPLICATIONS Sarcoma, Kaposi's/ETIOLOGY Simplexvirus/ISOLATION & PURIF Support, Non-U.S. Gov't Support, U.S. Gov't, P.H.S. Ulcer/ETIOLOGY JOURNAL ARTICLE

KWDadultanusdiseases/KWDetiologycandidiasis/complicationscasereportchronicdiseasecytomegalovirusinfections/complicationsherpessimplex/KWDetiology/immunologyKWDhomosexualityhumanKWDimmunity,cellularimmunologicdeficiencysyndromes/KWDetiologykillercells/immunologymalepneumonia,pneumocystiscarinii/complicationssarcoma,kaposi's/etiologysimplexvirus/isolation&purifsupport,non-uKWDsKWDgov'tsupport,uKWDsKWDgov't,pKWDhKWDsKWDulcer/etiologyjournalarticle
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Copyright © 1982 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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