Asymptomatic rectal mucosal lesions and hepatitis B surface antigen at sites of sexual contact in homosexual men with persistent hepatitis B virus infection. NLM AIDSLINE Important note: Information in this article was accurate in 1982. The state of the art may have changed since the publication date.

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Asymptomatic rectal mucosal lesions and hepatitis B surface antigen at sites of sexual contact in homosexual men with persistent hepatitis B virus infection.

Ann Intern Med. 1982 Feb;96(2):170-3. Unique Identifier : AIDSLINE MED/82133351
Reiner NE; Judson FN; Bond WW; Francis DP; Petersen NJ

Abstract: To ascertain why active and passive oral-anal and genital anal intercourse correlate strongly with hepatitis B virus (HBV) infection in homosexual men, we studied 22 men with HBV infection for the presence of hepatitis B surface antigen (HBsAg) in gingival and anorectal mucosa, feces, and semen. Thirteen of 22 (59%) patients had asymptomatic rectal mucosal lesions consisting of punctate bleeding points. Seventy-seven percent of swabbed specimens from lesions, 62% from feces, 59% from rectal mucosa, and 50% from anal canal mucosa contained HBsAg. Sera diluted serially and tested for HBsAg by radioimmunoassay showed that men with serum titers of 105 or greater were more likely to have HBsAg in specimens from lesions (p = 0.034), feces (p = 0.032), and normal mucosa (p = 0.001) than men with titers under 10 5. Asymptomatic rectal bleeding is frequent in homosexual men with persistent HBV infection. Rectal mucosa, feces, and anal canal mucosa become contaminated with HBsAg, creating a setting for de facto parenteral transmission when there is contact with oral or urethral mucosa.
Keywords: Feces/IMMUNOLOGY Gingiva/IMMUNOLOGY Hepatitis B/IMMUNOLOGY/*TRANSMISSION Hepatitis B Surface Antigens/*ANALYSIS *Homosexuality Human Intestinal Mucosa/*IMMUNOLOGY Male Mouth Mucosa/IMMUNOLOGY Rectum/*INJURIES Semen/IMMUNOLOGY Sex Behavior JOURNAL ARTICLE

KWDfeces/immunologygingiva/immunologyhepatitisb/immunology/KWDtransmissionhepatitisbsurfaceantigens/KWDanalysisKWDhomosexualityhumanintestinalmucosa/KWDimmunologymalemouthmucosa/immunologyrectum/KWDinjuriessemen/immunologysexbehaviorjournalarticle
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M8260012

Copyright © 1982 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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