In vitro differentiation of human marrow T cell precursors by thymic factors in severe combined immunodeficiency. NLM AIDSLINE Important note: Information in this article was accurate in 1982. The state of the art may have changed since the publication date.

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In vitro differentiation of human marrow T cell precursors by thymic factors in severe combined immunodeficiency.

Transplantation. 1981 Oct;32(4):299-305. Unique Identifier : AIDSLINE MED/82130166
Incefy GS; O'Reilly RJ; Kapoor N; Iwata T; Good RA

Abstract: Marrow cells from 16 patients with severe combined immunodeficiency diseases (SCID) were examined for the presence of T cell precursors which could be induced to express surface markers and functions of T lymphocytes after exposure in vitro to thymic extracts or peptides of thymic origin (thymopoietin and thymopoietin32-36 (TP-5). Marrow cells from 14 patients studied before transplantation revealed three patterns of response. In five patients, inducible T cell precursors were not detected. In six patients, precursors were detected which could be induced to express a human T lymphocyte antigen (HTLA) but acquired little or no ability to rosette with sheep erythrocytes (SRBCs). Induction of HTLA-positive and E rosette-positive lymphocytes was normal in only two patients, both of whom were engrafted with maternal lymphocytes as an apparent result of an intrauterine infusion. Induction of mixed leukocyte reaction (MLR) responses following exposure to thymic hormones was also observed in one of these two patients. In no case could significant responses to mitogens be elicited. Following transplantation, marrow cells from fully engrafted, immunologically reconstituted patients could be induced to bear HTLA, to form E rosettes, and to respond to mitogens and allogeneic cells following exposure to thymic extracts, thymopoietin, or TP-5. Thus, most patients with SCID manifest differentiative abnormalities intrinsic to lymphoid precursors which are corrected following engraftment of functioning allogeneic lymphoid precursors from normal donors.
Keywords: *Antigens, Surface Cell Differentiation Digeorge Syndrome/*IMMUNOLOGY Female Human Immunologic Deficiency Syndromes/*IMMUNOLOGY Infant Infant, Newborn Lymphocyte Transformation Male Mitogens/PHARMACOLOGY Rosette Formation Support, Non-U.S. Gov't Support, U.S. Gov't, P.H.S. T-Lymphocytes/CYTOLOGY/*IMMUNOLOGY Thymopoietins/*PHARMACOLOGY Thymus Hormones/*PHARMACOLOGY JOURNAL ARTICLE

KWDantigens,surfacecelldifferentiationdigeorgesyndrome/KWDimmunologyfemalehumanimmunologicdeficiencysyndromes/KWDimmunologyinfantinfant,newbornlymphocytetransformationmalemitogens/pharmacologyrosetteformationsupport,non-uKWDsKWDgov'tsupport,uKWDsKWDgov't,pKWDhKWDsKWDt-lymphocytes/cytology/KWDimmunologythymopoietins/KWDpharmacologythymushormones/KWDpharmacologyjournalarticle
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Copyright © 1982 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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