Antibodies to Epstein-Barr virus-specific antigens in patients with hairy-cell leukemia. NLM AIDSLINE Important note: Information in this article was accurate in 1982. The state of the art may have changed since the publication date.

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Antibodies to Epstein-Barr virus-specific antigens in patients with hairy-cell leukemia.

Int J Cancer. 1981;27(4):453-8. Unique Identifier : AIDSLINE MED/82006545
Sakamoto K; Aiba M; Katayama I; Sullivan JL; Humphreys RE; Purtilo DT

Abstract: Antibody titers to Epstein-Barr virus (EBV)-specific antigens of 19 patients with hairy-cell leukemia (HCL) were markedly elevated. All patients showed high titers of IgG anti-viral capsid antigen (VCA) reactivity equal to or greater than 320 (reciprocal titer). The anti-VCA reciprocal geometric mean titer (GTM) was 1106 in contrast to a GMT of 80 for healthy controls (p less than 0.001). No IgM anti-VCA antibody was detected, but three patients had IgA anti-VCA antibodies. Fourteen patients had elevated anti-early antigen (EA) titers (GMT = 177) which were indicative of active infections with EBV. Seven of the 14 patients demonstrated the diffuse component antibody of the early antigen (EA) complex at a GMT of 98. Anti-Epstein-Barr virus nuclear antigen (EBNA) was detected in sera of 16 patients (GMT = 64, controls GMT = 79). It is noteworthy that three patients with anti-VCA titers lacked anti-EBNA titers. These anti-body responses suggest that immunodeficiency secondary to HCL allowed reactivation of the virus.
Keywords: Adult Aged *Antibodies, Viral/ANALYSIS Antigens, Viral/*IMMUNOLOGY Capsid/IMMUNOLOGY Female Herpesvirus 4, Human/*IMMUNOLOGY Human IgA/ANALYSIS IgG/ANALYSIS IgM/ANALYSIS Leukemia, Hairy Cell/*IMMUNOLOGY Male Middle Age Support, U.S. Gov't, P.H.S. JOURNAL ARTICLE

KWDadultagedKWDantibodies,viral/analysisantigens,viral/KWDimmunologycapsid/immunologyfemaleherpesvirus4,human/KWDimmunologyhumaniga/analysisigg/analysisigm/analysisleukemia,hairycell/KWDimmunologymalemiddleagesupport,uKWDsKWDgov't,pKWDhKWDsKWDjournalarticle
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Copyright © 1982 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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