Antiviral properties of polyinosinic acids containing thio and methyl substitutions. NLM AIDSLINE Important note: Information in this article was accurate in 1982. The state of the art may have changed since the publication date.

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Antiviral properties of polyinosinic acids containing thio and methyl substitutions.

J Gen Virol. 1981 Feb;52(Pt 2):291-9. Unique Identifier : AIDSLINE MED/82032272
Chan EW; Lee CK; Dale PJ; Nortridge KR; Hom SS; Seed TM

Abstract: Polyinosinic acids containing methyl and sulphur substitutions are potent inhibitors of reverse transcriptase. Substitution of sulphur for oxygen at the 6 position produces significant effects on the properties of polyinosinic acid: the kinetics of inhibition change from competitive to mixed-type and the inhibition constant falls by three orders of magnitude. In contrast, 1-methyl substitution produces no such effects. Poly(1-methyl-6-thioinosinic acid) or poly(m1s6I) inhibits irreversibly, inhibiting all ten reverse transcriptases tested under a variety of assay conditions. In cell culture test systems, poly(m1s6I) is capable of blocking both infection by non-transforming viruses and transformation by a sarcoma virus. The presence of poly(m1s6I) in a preinfected culture results in the production of non-infectious virus particles lacking reverse transcriptase activity.
Keywords: Leukemia Virus, Feline/DRUG EFFECTS Myeloblastosis Virus, Avian/DRUG EFFECTS Poly I/*PHARMACOLOGY Polyribonucleotides/*PHARMACOLOGY Retroviridae/*DRUG EFFECTS/ENZYMOLOGY Reverse Transcriptase/*ANTAGONISTS & INHIB Sarcoma Viruses, Simian/DRUG EFFECTS Structure-Activity Relationship Support, U.S. Gov't, Non-P.H.S. Support, U.S. Gov't, P.H.S. Thionucleotides/*PHARMACOLOGY Tumor Viruses, Murine/DRUG EFFECTS Virus Replication/DRUG EFFECTS JOURNAL ARTICLE

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820228
M8220002

Copyright © 1982 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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