Treatment of cell-mediated immunodeficiency with calf thymic hormone (T.P.I.). NLM AIDSLINE Important note: Information in this article was accurate in 1982. The state of the art may have changed since the publication date.

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Treatment of cell-mediated immunodeficiency with calf thymic hormone (T.P.I.).

Pediatr Res. 1982 Jul;16(7):573-8. Unique Identifier : AIDSLINE MED/82273798
Davies EG; Levinsky RJ

Abstract: Eight children, four with combined immunodeficiencies and four with isolated T cell defects were treated with TPI, a crude calf thymic extract. Assessment of response was made on clinical grounds and by monitoring of immune function (T and B cell numbers, immunoglobulin levels, PHA response and delayed cutaneous reaction to Candida antigen). One child with severe combined immunodeficiency showed marked clinical improvement together with reconstitution of T cell numbers and, surprisingly, B cell numbers and immunoglobulin production. Two further children, one with a form of combined immunodeficiency and the other with a T cell defect and extensive cutaneous herpes simplex infection, showed benefit from therapy though in the latter we could not demonstrate that this was important in clearing the virus infection. None of the other children showed any consistent improvement either clinically or on testing. We found no evidence of toxicity, allergy or other adverse effects of therapy.
Keywords: Animal Antigens, Viral/IMMUNOLOGY B-Lymphocytes/DRUG EFFECTS Candida/IMMUNOLOGY Case Report Cattle Child Child, Preschool Female Human Immunity, Cellular/DRUG EFFECTS Immunologic Deficiency Syndromes/*DRUG THERAPY Infant Male Phytohemagglutinins/DIAGNOSTIC USE Support, Non-U.S. Gov't T-Lymphocytes/DRUG EFFECTS Thymus Extracts/*THERAPEUTIC USE Tissue Extracts/THERAPEUTIC USE JOURNAL ARTICLE

KWDanimalantigens,viral/immunologyb-lymphocytes/drugeffectscandida/immunologycasereportcattlechildchild,preschoolfemalehumanimmunity,cellular/drugeffectsimmunologicdeficiencysyndromes/KWDdrugtherapyinfantmalephytohemagglutinins/diagnosticusesupport,non-uKWDsKWDgov'tt-lymphocytes/drugeffectsthymusextracts/KWDtherapeuticusetissueextracts/therapeuticusejournalarticle
821230
M82C0014

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