In vitro induction of monoclonal antibody-defined T-cell markers in lymphocytes from immunodeficient children by synthetic serum thymic factor (FTS). NLM AIDSLINE Important note: Information in this article was accurate in 1982. The state of the art may have changed since the publication date.

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In vitro induction of monoclonal antibody-defined T-cell markers in lymphocytes from immunodeficient children by synthetic serum thymic factor (FTS).

Clin Exp Immunol. 1982 May;48(2):423-8. Unique Identifier : AIDSLINE MED/82260017
Bene MC; Faure G; Bordigoni P; Olive D; Duheille J

Abstract: Lymphocytes from five children suffering from ataxia telangectasia or various unclassified immune deficiencies were tested in vitro for their sensitivity to synthetic serum thymic factor (FTS). The percentages of cells bearing T cell markers were elevated after incubation with FTS at graded concentrations (0.25, 2.5 and 25 ng/ml), by microlymphocytotoxicity or indirect immunofluorescence, using monoclonal anti-Lyt1 antibodies. In four cases, more than 30% of the non-T non-B cells acquired the Lyt1 T cell marker. These four children had low levels of circulating FTS. In the fifth child, who had a normal serum FTS level, and in two age-matched controls, there was no significant increase in the percentage of cells bearing the T marker.
Keywords: Adolescence Antibodies, Monoclonal/IMMUNOLOGY Ataxia Telangiectasia/IMMUNOLOGY Child Child, Preschool Female Fluorescent Antibody Technique Human Immunologic Deficiency Syndromes/*IMMUNOLOGY Leukocyte Count Male T-Lymphocytes/*IMMUNOLOGY Thymic Factor, Circulating/*IMMUNOLOGY Thymus Hormones/*IMMUNOLOGY JOURNAL ARTICLE

KWDadolescenceantibodies,monoclonal/immunologyataxiatelangiectasia/immunologychildchild,preschoolfemalefluorescentantibodytechniquehumanimmunologicdeficiencysyndromes/KWDimmunologyleukocytecountmalet-lymphocytes/KWDimmunologythymicfactor,circulating/KWDimmunologythymushormones/KWDimmunologyjournalarticle
821230
M82C0013

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