Inherited 7S immunoglobulin deficiency of chickens is associated with bursal degeneration anomalies. NLM AIDSLINE Important note: Information in this article was accurate in 1982. The state of the art may have changed since the publication date.

Click here to return to AIDSLINE main menu
DonateNow
Print this Article


Inherited 7S immunoglobulin deficiency of chickens is associated with bursal degeneration anomalies.

Dev Comp Immunol. 1982 Winter;6(1):105-12. Unique Identifier : AIDSLINE MED/82165304
Erickson KL; Gershwin ME; Abplanalp H; Ikeda R; Benedict AA

Abstract: Partially inbred line UCD 140 chickens develop an age dependent inherited 7S immunoglobulin deficiency with features similar to acquired human agammaglobulinemia. Serial and developmental observations in line UCD 140 and control lines 440 and 444 reveal a significant progressive premature involution of the bursa of Fabricius. These bursal changes are characterized by epithelial and medullary degeneration, reduced follicular bursacyte mitosis, and decreased follicular plasma cells. These abnormalities have not been previously described in other avian systems and suggest that this immune deficiency is due to a primary bursal disease.
Keywords: Agammaglobulinemia/COMPLICATIONS/*IMMUNOLOGY/PATHOLOGY Aging Animal Bursa of Fabricius/*ABNORMALITIES/PATHOLOGY Chickens Endoplasmic Reticulum/ULTRASTRUCTURE IgG/*DEFICIENCY Marek's Disease/COMPLICATIONS/IMMUNOLOGY/PATHOLOGY Plasma Cells/ULTRASTRUCTURE Poultry Diseases/COMPLICATIONS/*IMMUNOLOGY/PATHOLOGY Support, Non-U.S. Gov't Support, U.S. Gov't, P.H.S. JOURNAL ARTICLE

KWDagammaglobulinemia/complications/KWDimmunology/pathologyaginganimalbursaoffabricius/KWDabnormalities/pathologychickensendoplasmicreticulum/ultrastructureigg/KWDdeficiencymarek'sdisease/complications/immunology/pathologyplasmacells/ultrastructurepoultrydiseases/complications/KWDimmunology/pathologysupport,non-uKWDsKWDgov'tsupport,uKWDsKWDgov't,pKWDhKWDsKWDjournalarticle
820830
M8280009

Copyright © 1982 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

AEGiS is a 501(c)3, not-for-profit, tax-exempt, educational corporation. AEGiS is made possible through unrestricted funding from Boehringer Ingelheim, Bridgestone/Firestone Charitable Trust, Bristol-Myers Squibb Company, Elton John AIDS Foundation, Gill Foundation, the National Library of Medicine, Quest Diagnostics, Roche and Trimeris, and donations from users like you. Always watch for outdated information. This article first appeared in 1982. This material is designed to support, not replace, the relationship that exists between you and your doctor.

AEGiS presents published material, reprinted with permission and neither endorses nor opposes any material. All information contained on this website, including information relating to health conditions, products, and treatments, is for informational purposes only. It is often presented in summary or aggregate form. It is not meant to be a substitute for the advice provided by your own physician or other medical professionals. Always discuss treatment options with a doctor who specializes in treating HIV.

Copyright ©1980, 1982. AEGiS. All materials appearing on AEGiS are protected by copyright as a collective work or compilation under U.S. copyright and other laws and are the property of AEGiS, or the party credited as the provider of the content. .