Documentation of Epstein-Barr virus infection in immunodeficient patients with life-threatening lymphoproliferative diseases by Epstein-Barr virus complementary RNA/DNA and viral DNA/DNA hybridization.

Important note: Information in this article was accurate in 1982. The state of the art may have changed since the publication date.

Cancer Res. 1981 Nov;41(11 Pt 1):4237-42. Unique Identifier : AIDSLINE MED/82070026
Saemundsen AK; Purtilo DT; Sakamoto K; Sullivan JL; Synnerholm AC; Hanto D; Simmons R; Anvret M; Collins R; Klein G

Abstract: Tissues from patients thought to have Epstein-Barr virus (EBV)-induced lymphoproliferative diseases were probed for EBV genomes using 2 independent hybridization techniques. Tissues from six patients with the X-linked lymphoproliferative syndrome, all five renal allograft recipients with immunoblastic sarcoma, and eight patients with diverse types of immunodeficiency and lymphoproliferative diseases such as fatal infectious mononucleosis or malignant lymphoma associated with antecedent immunodeficiency contained significant numbers of EBV genome equivalents per cell. The use of 2 hybridization probes is recommended to confirm the presence of EBV genomes. The finding of significant numbers of EBV genomes in tissues from patients with immunodeficiency suggests that EBV is the etiological agent of the associated lymphoproliferative diseases.

Keywords: Adolescence Animal Child Child, Preschool Comparative Study DNA, Viral/ISOLATION & PURIF *Genes, Viral Herpesvirus 4, Human/*GENETICS/ULTRASTRUCTURE Human Immunologic Deficiency Syndromes/*MICROBIOLOGY Infectious Mononucleosis/IMMUNOLOGY/MICROBIOLOGY Lymph Nodes/ULTRASTRUCTURE Lymphoma/IMMUNOLOGY/MICROBIOLOGY Lymphoproliferative Disorders/IMMUNOLOGY/*MICROBIOLOGY Middle Age Nucleic Acid Hybridization RNA, Viral/ISOLATION & PURIF Support, U.S. Gov't, P.H.S. Tumor Virus Infections/IMMUNOLOGY/*MICROBIOLOGY JOURNAL ARTICLE

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