Natural history of liver disease in chronic hepatitis B surface antigen carriers. Survey of 100 patients from Great Britain. NLM AIDSLINE Important note: Information in this article was accurate in 1982. The state of the art may have changed since the publication date.

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Natural history of liver disease in chronic hepatitis B surface antigen carriers. Survey of 100 patients from Great Britain.

Lancet. 1981 Nov 21;2(8256):1156-9. Unique Identifier : AIDSLINE MED/82079588
Viola LA; Barrison IG; Coleman JC; Paradinas FJ; Fluker JL; Evans BA; Murray-Lyon IM

Abstract: 100 consecutive British chronic carriers of hepatitis B surface antigen seen in a London teaching hospital are described. 77 were male homosexuals and only 19 had either symptoms or signs of chronic liver disease. 27 had normal liver function tests and 69 of the remaining patients had minimal changes, chronic persistent hepatitis, chronic active hepatitis, cirrhosis, or hepatocellular carcinoma diagnosed on liver biopsy. The 4 remaining patients did not have a biopsy but did have abnormal liver function tests. Chronic hepatitis B virus infection was an important cause of these conditions. Most patients showed no clinical, biochemical, or histological change during a mean follow-up period of 44 months, and only 9.7% spontaneously seroconverted from hepatitis B antigen positivity to become anti-hepatitis B e antibody carriers. Although the prognosis is good in the medium term, 7 patients died from hepatocellular carcinoma.
Keywords: Adolescence Adult Aged Biopsy Carrier State/*EPIDEMIOLOGY/IMMUNOLOGY Child Chronic Disease Female Great Britain Hepatitis B/*EPIDEMIOLOGY Hepatitis B Antibodies/ANALYSIS Hepatitis B Surface Antigens/*ANALYSIS Homosexuality Human Liver/PATHOLOGY Liver Diseases/*EPIDEMIOLOGY/IMMUNOLOGY/PATHOLOGY Male Middle Age Support, Non-U.S. Gov't JOURNAL ARTICLE

KWDadolescenceadultagedbiopsycarrierstate/KWDepidemiology/immunologychildchronicdiseasefemalegreatbritainhepatitisb/KWDepidemiologyhepatitisbantibodies/analysishepatitisbsurfaceantigens/KWDanalysishomosexualityhumanliver/pathologyliverdiseases/KWDepidemiology/immunology/pathologymalemiddleagesupport,non-uKWDsKWDgov'tjournalarticle
820430
M8240004

Copyright © 1982 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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