Three distinct genes in human DNA related to the transforming genes of mammalian sarcoma retroviruses. NLM AIDSLINE Important note: Information in this article was accurate in 1981. The state of the art may have changed since the publication date.

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Three distinct genes in human DNA related to the transforming genes of mammalian sarcoma retroviruses.

Science. 1981 Jul 10;213(4504):226-8. Unique Identifier : AIDSLINE MED/81225821
Wong-Staal F; Dalla-Favera R; Franchini G; Gelmann EP; Gallo RC

Abstract: Southern blot hybridization was used to identify human and other vertebrate DNA sequences that were homologous to cloned DNA fragments containing the oncogenic nucleic acid sequences of three different type C mammalian retroviruses (simian sarcoma virus, the Snyder-Theilen strain of feline sarcoma virus, and the Harvey strain of murine sarcoma virus). Each onc gene counterpart has a single genetic locus, which probably contains non-onc intervening sequences. The human DNA sequences may represent genes important to cell growth or cell differentiation, or both. Their identification and isolation may allow elucidation of their role in these processes and in neoplasias.
Keywords: Animal Base Sequence *Cell Transformation, Viral *Cloning, Molecular DNA/*GENETICS DNA, Viral/*GENETICS *Genes Human Nucleic Acid Hybridization Retroviridae/*GENETICS Sarcoma Viruses, Murine/GENETICS Sarcoma Viruses, Simian/GENETICS Species Specificity JOURNAL ARTICLE

KWDanimalbasesequenceKWDcelltransformation,viralKWDcloning,moleculardna/KWDgeneticsdna,viral/KWDgeneticsKWDgeneshumannucleicacidhybridizationretroviridae/KWDgeneticssarcomaviruses,murine/geneticssarcomaviruses,simian/geneticsspeciesspecificityjournalarticle
811030
M81A0002

Copyright © 1981 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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