Atopy does not predispose to RSV bronchiolitis or postbronchiolitic wheezing. NLM AIDSLINE Important note: Information in this article was accurate in 1981. The state of the art may have changed since the publication date.

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Atopy does not predispose to RSV bronchiolitis or postbronchiolitic wheezing.

Br Med J (Clin Res Ed). 1981 Jun 27;282(6282):2086-8. Unique Identifier : AIDSLINE MED/81233751
Sims DG; Gardner PS; Weightman D; Turner MW; Soothill JF

Abstract: Twenty-six 8-year-old children who had had respiratory syncytial virus (RSV) bronchiolitis in infancy and their paired controls underwent skin and blood tests to assess the role of immunodeficiency and atopy in the pathogenesis of RSV bronchiolitis and the wheezing that may follow it. There was no difference between patients and controls in prevalence of atopy; positive results of prick tests to common antigens; eosinophil counts; yeast opsonisation defect; C2 deficiency; IgG, IgA, IgM, and IgE concentrations; or IgE antibody to dermatophagoides, timothy-grass pollen, and cat fur. Those of the children who had had RSV bronchiolitis and who continued to wheeze had a slightly higher mean eosinophil count and levels of IgE antibody to dermatophagoides than those who did not wheeze. Exercise-induced bronchial lability, though higher in patients than controls, did not correlate significantly with eosinophil counts or IgE concentrations. The genetic factors predisposing to RSV bronchiolitis and postbronchiolitic wheezing may differ from those predisposing to atopic asthma, though exclusive breast feeding may protect against both.
Keywords: Bronchiolitis, Viral/*ETIOLOGY Child Female Human Hypersensitivity/*COMPLICATIONS Immunologic Deficiency Syndromes/COMPLICATIONS Male Paramyxovirus Infections/*ETIOLOGY Respiratory Sounds Respiratory Syncytial Viruses JOURNAL ARTICLEKWDbronchiolitis,viral/KWDetiologychildfemalehumanhypersensitivity/KWDcomplicationsimmunologicdeficiencysyndromes/complicationsmaleparamyxovirusinfections/KWDetiologyrespiratorysoundsrespiratorysyncytialvirusesjournalarticle
811130
M81B0010

Copyright © 1981 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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