Inhibition of reverse transcriptase by polyvinyl sulfate (PVS). NLM AIDSLINE Important note: Information in this article was accurate in 1981. The state of the art may have changed since the publication date.

Click here to return to AIDSLINE main menu
DonateNow
Print this Article


Inhibition of reverse transcriptase by polyvinyl sulfate (PVS).

Cancer Biochem Biophys. 1981;5(2):97-101. Unique Identifier : AIDSLINE MED/81234232
Hallinan FM; Lee SH; Rozee KR

Abstract: The effect of the ribonuclease inhibitor polyvinyl sulfate on the activity of retroviral DNA polymerase and terminal c transferase was examined. This substance was found to be a potent inhibitor of these enzymes by virtue of competition between the sulfated sidechains of the molecule and the template primer for a site on the enzyme. The significance of these findings in relation to searching for reverse transcriptase is discussed.
Keywords: Comparative Study DNA Nucleotidyltransferases/ANTAGONISTS & INHIB DNA Polymerases/ANTAGONISTS & INHIB Kinetics Moloney Leukemia Virus/ENZYMOLOGY Polyvinyls/*PHARMACOLOGY Rauscher Virus/ENZYMOLOGY Retroviridae/*ENZYMOLOGY Reverse Transcriptase/*ANTAGONISTS & INHIB Sarcoma Viruses, Simian/ENZYMOLOGY Species Specificity Support, Non-U.S. Gov't JOURNAL ARTICLEKWDcomparativestudydnanucleotidyltransferases/antagonists&inhibdnapolymerases/antagonists&inhibkineticsmoloneyleukemiavirus/enzymologypolyvinyls/KWDpharmacologyrauschervirus/enzymologyretroviridae/KWDenzymologyreversetranscriptase/KWDantagonists&inhibsarcomaviruses,simian/enzymologyspeciesspecificitysupport,non-uKWDsKWDgov'tjournalarticle
811130
M81B0007

Copyright © 1981 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

AEGiS is a 501(c)3, not-for-profit, tax-exempt, educational corporation. AEGiS is made possible through unrestricted funding from Boehringer Ingelheim, Bridgestone/Firestone Charitable Trust, Bristol-Myers Squibb Company, Elton John AIDS Foundation, Gill Foundation, the National Library of Medicine, Quest Diagnostics, Roche and Trimeris, and donations from users like you. Always watch for outdated information. This article first appeared in 1981. This material is designed to support, not replace, the relationship that exists between you and your doctor.

AEGiS presents published material, reprinted with permission and neither endorses nor opposes any material. All information contained on this website, including information relating to health conditions, products, and treatments, is for informational purposes only. It is often presented in summary or aggregate form. It is not meant to be a substitute for the advice provided by your own physician or other medical professionals. Always discuss treatment options with a doctor who specializes in treating HIV.

Copyright ©1980, 1981. AEGiS. All materials appearing on AEGiS are protected by copyright as a collective work or compilation under U.S. copyright and other laws and are the property of AEGiS, or the party credited as the provider of the content. .