The etiology, diagnosis, monitoring, and therapy of cell-mediated immune deficiency (CMID) is discussed. CMID is a condition in which T-lymphocytes, which are developmentally and functionally dependent on the thymus, are absent or deficient at some level. CMID can be subclassified into two distinct types: the congenit
Epstein-Barr virus and hepatitis B virus are two agents which chronically infect man and have been associated with specific neoplasms. Such findings point the way to new methods of control and detection of human malignancies. Furthermore, immunosuppression is another major factor underlying the development of certain
Von Daniken A; Lutz WK; Schlatter C; Inst. Toxicology, Swiss Federal Inst. Technology, Schwerzenbach; CH-8603, Switzerland
Labeled clofibric or fenofibric acid was administered po to Sprague-Dawley derived SIV 50 rats, and 10 hr later, the animals were sacrificed and the nuclear DNA and protein were isolated from the livers. 14C-Label was detected in protein (9-78 disintegrations/min); however, radioactivity levels in the DNA were just ab
Am J Epidemiol. 1981 Feb;113(2):113-21. Unique Identifier : AIDSLINE MED/81130778
Szmuness W; Neurath AR; Stevens CE; Strick N; Harley EJ
A total of 749 persistent carriers of hepatitis B surface antigen (HBsAg) were tested for hepatitis B e antigen/antibody to e antigen (HBeAg/anti-HBe) by a radioimmunoassay method. The prevalence of HBeAg was found to be: 9.1% in carrier-blood donors, 10.3% in mentally retarded patients without Down s syndrome, 23.6%
Am J Med. 1981 Feb;70(2):412-6. Unique Identifier : AIDSLINE MED/81130863
Hughes WT; Townsend TR
Within the last decade several advances in medicine have resulted in extended longevity of children with cancer, cystic fibrosis, certain congenital immunodeficiency disorders, chronic renal diseases and aplastic anemia. Forthwith, the population of such immunocompromised children has increased and accounts for a grea
The X-linked lymphoproliferative syndrome (XLP) is characterized by a combined variable immunodeficiency with vulnerability to Epstein-Barr virus (EBV)-induced fatal or chronic infectious mononucleosis, acquired agammaglobulinemia, aplastic anemia, or malignant B cell lymphomas. Diagnosis of XLP requires documentation
J Gen Virol. 1980 Oct;50(2):247-57. Unique Identifier : AIDSLINE MED/81118903
Bergholz CM; Reynolds JT; Panem S
The biological and antigenic properties of HEL-12 virus have been compared with gibbon ape lymphosarcoma virus (GALV) and simian sarcoma and simian sarcoma-associated viruses, SiSV and SSAV, respectively, HEL-12 virus did not transform human or marmoset fibroblasts but rescued SiSV focus-forming activity from non-prod
In a prospective study 43 consecutive children in hospital, aged between 6 months and 7 years and displaying at least one of the clinical signs of infectious mononucleosis (IM), were investigated for Epstein-Barr (EB) virus-specific IgM antibodies by an indirect immunofluorescence test. On this basis EB virus infectio
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