ETIOLOGIC FACTORS IN NON-HODGKIN'S LYMPHOMA.

Important note: Information in this article was accurate in 1981. The state of the art may have changed since the publication date.

ETIOLOGIC FACTORS IN NON-HODGKIN'S LYMPHOMA.

Non-Hodgkin's Lymphomas in Children. Graham-Pole J, ed. New York, Masson Publishing USA, Inc., Masson Monographs in Pediatric Hematology/Oncology, 177 pp., 1980.. Unique Identifier : AIDSLINE ICDB/81616020
Leventhal BG; Kaizer H; Oncology Center, Dept. Pediatrics, Johns Hopkins Univ., Sch.; Medicine, 601 N. Broadway, Baltimore, MD, 21205

Abstract: The potential etiologic role of virus, cytogenetic abnormalities, and immunodeficiency states in non-Hodgkin's lymphoma (NHL) is discussed. Recent observations suggesting that some NHLs represent complex examples of the breakdown of normal immune responses are emphasized. These include the occurrence of chromosome 14 abnormalities in B-cell tumors, the association between NHLs and genetically determined immunodeficiency diseases, the role of Epstein-Barr virus in Duncan's familial immunodeficiency disorder, the occurrence of a fatal polyclonal B-cell immunoblastic lymphoproliferative disorder after thymic transplantation in patients with combined immunodeficiency disease, the development of histiocytic lymphomas or immunoblastic sarcomas in renal transplant patients, and the increased incidence of NHLs in patients with autoimmune disease such as Sjogren's disease or systemic lupus erythematosus. Chronic antigenic stimulation leading to unchecked lymphoma proliferation could be an etiologic factor common to hereditary and acquired immunodeficiency diseases, oncogenic viral infections, and autoimmune diseases. (49 Refs)

Keywords: MONOGRAPH REVIEW
810730
M8170008

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