Selective IgA deficiency and the HLA-B8 antigen. Report of two cases with familial data. NLM AIDSLINE Important note: Information in this article was accurate in 1981. The state of the art may have changed since the publication date.

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Selective IgA deficiency and the HLA-B8 antigen. Report of two cases with familial data.

Arch Intern Med. 1981 Mar;141(4):509-10. Unique Identifier : AIDSLINE MED/81159178
Perez-Jimenez F; Lopez PB; Tallo EP; Guzman JR; Molina JS; Pereperez JA

Abstract: Two patients had IgA deficiency, giardiasis, and the HLA-B8 antigen. The family of patient 1 included members with juvenile-onset diabetes mellitus, adrenal insufficiency, pernicious anemia, and hypothyroidism, a combination of unusual diseases that has been reported previously to occur as a syndrome with IgA deficiency and the HLA-B8 antigen. This coincidence makes it likely that these two patients and the one family previously described have a common pathogenic base, the inheritance of an abnormal immune-response gene that is acquired with the HLA-B8 antigen as a result of genetic dysequilibrium.
Keywords: Adult Case Report Child Dysgammaglobulinemia/COMPLICATIONS/*GENETICS/IMMUNOLOGY Giardiasis/COMPLICATIONS Human HLA Antigens/*GENETICS IgA/ANALYSIS/*DEFICIENCY IgG/ANALYSIS IgM/ANALYSIS Male JOURNAL ARTICLEKWDadultcasereportchilddysgammaglobulinemia/complications/KWDgenetics/immunologygiardiasis/complicationshumanhlaantigens/KWDgeneticsiga/analysis/KWDdeficiencyigg/analysisigm/analysismalejournalarticle
810730
M8170006

Copyright © 1981 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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