T lymphocyte subpopulations and Ia-positive T cells in patients with immunodeficiency.

Important note: Information in this article was accurate in 1981. The state of the art may have changed since the publication date.

T lymphocyte subpopulations and Ia-positive T cells in patients with immunodeficiency.

Clin Exp Immunol. 1980 Nov;42(2):355-63. Unique Identifier : AIDSLINE MED/81136487
Williams RC Jr; Webster AD; Morito T; Greaves MF

Abstract: T lymphocyte subpopulations (T gamma and Tmu) were studied in a group of 36 adult patients with immunodeficiency. Proportions and numbers of Ia(+) T cells were also studied in comparison to 46 normal adult controls. Values for per cent and total numbers of T gamma and Tmu cells indicated no uniform abnormality. Mean normal percentage of Ia(+) T cells was 2.4% whereas 16 to 29 immunodeficient patients showed elevated proportions and absolute numbers of Ia(+) T cells. Striking fluctuation in proportions of Ia(+) T cells was noted in serial studies of five immunodeficient subjects in contrast to similar analyses of normal controls. A correlation (P less than 0.01) was recorded between absolute numbers of Ia(+) T cells in immune deficiency patients and numbers of T mu cells. Depletion of T gamma cells by EA rosetting in patients with late-onset primary acquired hypogammaglobulinaemia did not result in significant change in IgG or IgM synthesis with T gamma-depleted T cells were co-cultured with normal B cells. Depletion of Ia(+) T cells likewise did not significantly influence Ig synthesis in co-culture with normal or immune-deficient B cells. These studies emphasize the complexity of defects present among any large group of patients with immune deficiency.

Keywords: Adult B-Lymphocytes/IMMUNOLOGY Histocompatibility Antigens Class II/*ANALYSIS Human IgG/IMMUNOLOGY IgM/IMMUNOLOGY Immunoglobulins/BIOSYNTHESIS Immunologic Deficiency Syndromes/*IMMUNOLOGY Infant Receptors, Fc/ANALYSIS Rosette Formation Support, Non-U.S. Gov't Support, U.S. Gov't, P.H.S. T-Lymphocytes/*CLASSIFICATION/IMMUNOLOGY JOURNAL ARTICLE
810730
M8170005

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