Immunodeficiency associated with loss of T4+ inducer T-cell function. NLM AIDSLINE Important note: Information in this article was accurate in 1981. The state of the art may have changed since the publication date.

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Immunodeficiency associated with loss of T4+ inducer T-cell function.

N Engl J Med. 1981 Apr 2;304(14):811-6. Unique Identifier : AIDSLINE MED/81148666
Reinherz EL; Geha R; Wohl ME; Morimoto C; Rosen FS; Schlossman SF

Abstract: We investigated the immune function of a patient with anergy and acquired hypogammaglobulinemia. Despite normal numbers of B cells and T4+ inducer and T5+ suppressor T cells, this patient's lymphocytes did not produce immunoglobulin, proliferate in response to soluble antigens, or generate helper factors in vitro. In addition, her T4+ T cells did not express la molecules after stimulation by soluble antigen. In mixing experiments, her T cells did not induce immunoglobulin secretion by B cells from a normal, HLA-D-identical sibling; this failure was not due to excessive suppression, since the patient's T cells did not abrogate immunoglobulin production by the normal sibling's T and B cells. Moreover, the patient's B cells secreted immunoglobulin in the presence of the sibling's T4+ cells. In contrast to the deficient inducer cells, the patient's T5+ T cells were capable of expressing suppressor-cell functions. These results indicate that immunodeficiency may occur because of a selective loss of T4+ inducer function.
Keywords: Agammaglobulinemia/IMMUNOLOGY Antibody Formation Case Report Child Concanavalin A/PHARMACOLOGY Female Histocompatibility Antigens Class II/IMMUNOLOGY Human Immunologic Deficiency Syndromes/*IMMUNOLOGY Isoantigens/IMMUNOLOGY Lymphocyte Culture Test, Mixed Lymphocyte Transformation Support, U.S. Gov't, P.H.S. T-Lymphocytes/*IMMUNOLOGY JOURNAL ARTICLEKWDagammaglobulinemia/immunologyantibodyformationcasereportchildconcanavalina/pharmacologyfemalehistocompatibilityantigensclassii/immunologyhumanimmunologicdeficiencysyndromes/KWDimmunologyisoantigens/immunologylymphocyteculturetest,mixedlymphocytetransformationsupport,uKWDsKWDgov't,pKWDhKWDsKWDt-lymphocytes/KWDimmunologyjournalarticle
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Copyright © 1981 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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