Antibody-specific immunoregulation and the immunodeficiency of aging. NLM AIDSLINE Important note: Information in this article was accurate in 1981. The state of the art may have changed since the publication date.

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Antibody-specific immunoregulation and the immunodeficiency of aging.

J Exp Med. 1981 Aug 1;154(2):547-51. Unique Identifier : AIDSLINE MED/81266045
Klinman NR

Abstract: Experiments were carried out to assess the role of naturally acquired antibody-specific immunoregulation in the immunodeficiency of aged individuals. It was found that greater than 50% of the primary dinitrophenyl-specific BALB/c B cells did not respond in carrier-primed 2-yr-old BALB/c adoptive hosts as compared with similarly primed younger recipients. Similar suppression was observed in carrier-primed younger BALB/c mice that had received 4 x 10(7) spleen cells from 2-yr-old BALB/c mice, as opposed to those that had received 4 x 10(7) spleen cells from younger mice. This diminution in responsiveness was noted only for syngeneic BALB/c B cells because B cells of strains differing from BALB/c in the heavy chain allotype-idiotype locus were not suppressed. These findings indicate that old, but not young, mice had developed the capacity to suppress primary B cells bearing receptors expressing much of the syngeneic antibody repertoire. This suppression may play an important causative role in the relatively poor humoral immune responsiveness of aged individuals.
Keywords: *Aging Animal *Antibody Specificity B-Lymphocytes/IMMUNOLOGY Immune Tolerance Immunization, Passive Immunologic Deficiency Syndromes/IMMUNOLOGY Male Mice Mice, Inbred BALB C/IMMUNOLOGY Support, U.S. Gov't, P.H.S. JOURNAL ARTICLEKWDaginganimalKWDantibodyspecificityb-lymphocytes/immunologyimmunetoleranceimmunization,passiveimmunologicdeficiencysyndromes/immunologymalemicemice,inbredbalbc/immunologysupport,uKWDsKWDgov't,pKWDhKWDsKWDjournalarticle
811230
M81C0003

Copyright © 1981 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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