Comparative oligonucleotide analysis of exogenous and endogenous primate type C viruses. NLM AIDSLINE Important note: Information in this article was accurate in 1981. The state of the art may have changed since the publication date.

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Comparative oligonucleotide analysis of exogenous and endogenous primate type C viruses.

J Gen Virol. 1981 Apr;53(Pt 2):283-92. Unique Identifier : AIDSLINE MED/81266184
Hefti E; Panem S

Abstract: RNAs of representative viruses of the exogenous simian sarcoma virus-gibbon ape lymphosarcoma virus (SiSV/GALV) and endogenous baboon virus (BaEV) classes of subhuman primate type C viruses were compared and related to HEL-12 virus, an isolate derived from human embryonic lung cells. The extent of sequence identity between different viral RNA preparations was determined by comparison of fingerprint patterns obtained after electrophoretic separation of RNase T1-resistant oligonucleotides. The studies presented indicate that HEL-12 viral RNA and simian sarcoma-simian associated virus [SiSV(SSAV)] RNA share 90 to 95% of the large oligonucleotides. From 5 to 10% of virus-specific oligonucleotides were detected in each of several virus preparations examined and their occurrence was independent of the cell line on which the virus ws propagated. HEL-12 virus and GALV-SF have 50% unique oligonucleotides in common. These are the same oligonucleotides that are shared between GALV-SF and SisV(SSAV) RNA. Two BaEV isolates, M7 and BILN, and RD114, and BaEV-related endogenous virus of cats, each easily displayed distinguishable oligonucleotides patterns. Large oligonucleotides characteristic for these three endogenous virus isolates were not detected in the fingerprints of HEL-12 virus, SiSV(SSAV) and GALV-SF.
Keywords: Animal Comparative Study *Genes, Viral Human Hylobates/MICROBIOLOGY Oligonucleotides/*ANALYSIS Oligoribonucleotides/*ANALYSIS Papio/MICROBIOLOGY Retroviridae/*ANALYSIS/GENETICS RNA, Viral/*ANALYSIS Sarcoma Viruses, Simian/*ANALYSIS/GENETICS Support, Non-U.S. Gov't JOURNAL ARTICLEKWDanimalcomparativestudyKWDgenes,viralhumanhylobates/microbiologyoligonucleotides/KWDanalysisoligoribonucleotides/KWDanalysispapio/microbiologyretroviridae/KWDanalysis/geneticsrna,viral/KWDanalysissarcomaviruses,simian/KWDanalysis/geneticssupport,non-uKWDsKWDgov'tjournalarticle
811230
M81C0002

Copyright © 1981 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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