Similar kinetic characteristics of 5-hydroxytryptamine binding in blood platelets and brain membranes of rats. NLM AIDSLINE Important note: Information in this article was accurate in 1981. The state of the art may have changed since the publication date.

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Similar kinetic characteristics of 5-hydroxytryptamine binding in blood platelets and brain membranes of rats.

Neurosci Lett. 1980 Dec;20(3):319-22. Unique Identifier : AIDSLINE MED/81075541
Von Hahn HP; Honegger CG; Pletscher A

Abstract: Blood platelets and brain membranes of SIV and Lewis rats both exhibited two saturable binding sites for 5-hydroxytryptamine (5-HT) in the concentration range 1-100 nM. The Kd values for the high-affinity sites were 4-6 nM and for the low-affinity sites 20-40 nM in both tissues of both rat strains. Blood platelets had 100-200 times more binding sites per mg protein (Bmax) than brain membranes. Thus, 5-HT receptors of platelets may be used as models for those of cerebral 5-HT-neurons.
Keywords: Animal Binding Sites Blood Platelets/ANALYSIS/*METABOLISM Brain/*METABOLISM Brain Chemistry Comparative Study Female Kinetics Membranes/METABOLISM Rats Rats, Inbred Lew Receptors, Serotonin/ANALYSIS Serotonin/*METABOLISM JOURNAL ARTICLEKWDanimalbindingsitesbloodplatelets/analysis/KWDmetabolismbrain/KWDmetabolismbrainchemistrycomparativestudyfemalekineticsmembranes/metabolismratsrats,inbredlewreceptors,serotonin/analysisserotonin/KWDmetabolismjournalarticle
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M8140002

Copyright © 1981 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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