RNA-dependent DNA polymerase activity in ocular granulocytic sarcoma associated to acute myelomonocytic leukemia in Turkish children. Biochemical and immunological characterization of the enzyme.

Important note: Information in this article was accurate in 1980. The state of the art may have changed since the publication date.

RNA-dependent DNA polymerase activity in ocular granulocytic sarcoma associated to acute myelomonocytic leukemia in Turkish children. Biochemical and immunological characterization of the enzyme.

Cancer Lett. 1980 Mar;9(1):67-74. Unique Identifier : AIDSLINE MED/80176878
Chandra P; Steel LK

Abstract: The present study describes the separation and purification of a reverse transciptiase from an orbital tumor of a patient with acute myelomonocytic leukemia. Specific reaction conditions with respect to ionic requirements and template-primers are reported. The purified enzyme was able to transcribe (rA)n . (dT)12, (rC)n . (dG)12, (OMeC)n . (dg)12 and the 70 S RNA from R(Mu)LV. Serological studies that the reverase transcriptase is antigenically related to reverse transcriptase from the type C woolly monkey virus-gibbon ape leukemia virus group.

Keywords: Animal Antibodies, Viral/IMMUNOLOGY Child Haplorhini Human Leukemia, Myelocytic, Acute/COMPLICATIONS/*ENZYMOLOGY Orbital Neoplasms/*ENZYMOLOGY/SECONDARY Retroviridae/IMMUNOLOGY Reverse Transcriptase/ANALYSIS/IMMUNOLOGY/*ISOLATION & PURIF Sarcoma Viruses, Simian/IMMUNOLOGY Transcription, Genetic Turkey JOURNAL ARTICLE
800930
M8090003

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