Relationship of retroviruses isolated from human leukemia tissues to the woolly monkey-gibbon ape leukemia viruses. NLM AIDSLINE Important note: Information in this article was accurate in 1980. The state of the art may have changed since the publication date.

Click here to return to AIDSLINE main menu
DonateNow
Print this Article


Relationship of retroviruses isolated from human leukemia tissues to the woolly monkey-gibbon ape leukemia viruses.

J Virol. 1980 May;34(2):390-401. Unique Identifier : AIDSLINE MED/80185148
Sahagan BG; Haseltine WA

Abstract: Retroviruses have been isolated from the tissues of human leukemia patients. Previous studies have shown that these isolates share some antigenic determinants with the family of viruses isolated from the woolly monkey and gibbon ape and that they exhibit partial nuclei acid homology with this same group of viruses. We have compared the RNAs of the viruses by two-dimensional polyacrylamide gel electrophoresis of the large RNase T1-resistant oligonucleotides. The degree of sequence identity between the RNAs was determined by the similarity of their RNase T1-resistant oligonucleotide pattern on gels, fingerprints, and in some cases by partial sequence analysis of individual oligonucleotides. This technique permits us to determine the degree of sequence identity among related RNA species. From our studies we conclude that viruses isolated from the tissues of two human leukemia patients, A1476 and SKA 21-3, as well as some subcultures of a virus isolated from the leukemic tissues of a third patient, HL23V, are closely related to the wooly monkey virus. However, the fingerprints of other HL23 viral isolates are very similar to that of GaLVSF, a gibbon ape leukemia virus isolated from a lymphosarcoma.
Keywords: Animal Base Sequence Comparative Study *Genes, Viral Human Hylobates/MICROBIOLOGY Leukemia, Lymphocytic/*MICROBIOLOGY Leukemia, Myelocytic, Acute/*MICROBIOLOGY Oligoribonucleotides/ANALYSIS Retroviridae/*GENETICS RNA, Viral/*ANALYSIS/GENETICS Sarcoma Viruses, Simian/GENETICS Support, U.S. Gov't, P.H.S. JOURNAL ARTICLEKWDanimalbasesequencecomparativestudyKWDgenes,viralhumanhylobates/microbiologyleukemia,lymphocytic/KWDmicrobiologyleukemia,myelocytic,acute/KWDmicrobiologyoligoribonucleotides/analysisretroviridae/KWDgeneticsrna,viral/KWDanalysis/geneticssarcomaviruses,simian/geneticssupport,uKWDsKWDgov't,pKWDhKWDsKWDjournalarticle
800930
M8090002

Copyright © 1980 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

AEGiS is a 501(c)3, not-for-profit, tax-exempt, educational corporation. AEGiS is made possible through unrestricted funding from Boehringer Ingelheim, Bridgestone/Firestone Charitable Trust, Bristol-Myers Squibb Company, Elton John AIDS Foundation, Gill Foundation, the National Library of Medicine, Quest Diagnostics, Roche and Trimeris, and donations from users like you. Always watch for outdated information. This article first appeared in 1980. This material is designed to support, not replace, the relationship that exists between you and your doctor.

AEGiS presents published material, reprinted with permission and neither endorses nor opposes any material. All information contained on this website, including information relating to health conditions, products, and treatments, is for informational purposes only. It is often presented in summary or aggregate form. It is not meant to be a substitute for the advice provided by your own physician or other medical professionals. Always discuss treatment options with a doctor who specializes in treating HIV.

Copyright ©1980, 1980. AEGiS. All materials appearing on AEGiS are protected by copyright as a collective work or compilation under U.S. copyright and other laws and are the property of AEGiS, or the party credited as the provider of the content. .