Specificity of human antibodies to oncovirus glycoproteins: recognition of antigen by natural antibodies directed against carbohydrate structures. NLM AIDSLINE Important note: Information in this article was accurate in 1980. The state of the art may have changed since the publication date.

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Specificity of human antibodies to oncovirus glycoproteins: recognition of antigen by natural antibodies directed against carbohydrate structures.

Proc Natl Acad Sci U S A. 1980 Mar;77(3):1622-6. Unique Identifier : AIDSLINE MED/80190107
Snyder HW Jr; Fleissner E

Abstract: Antibodies in human sera from healthy individuals were shown to be reactive with highly purified 70,000-dalton envelope glycoprotein (gp70) of the simian sarcoma virus-simian sarcoma-associated virus (SSV-SSAV) complex in radioimmunoprecipitation assays under certain conditions. The specificity of the reaction was analyzed in absorption tests with normal human serum proteins, assays of viral gp70 antigenicity after exposure to exo- and endoglycosidases or trypsin, and carbohydrate hapten inhibition studies. On the basis of the results obtained in these experiments we have concluded that immune recognition of SSV-SSAV gp70 can be mediated by naturally occurring heterophil antibodies in human sera that are reactive by virtue of binding to the carbohydrate moiety of the viral gp70 molecules. The results are consistent with the idea that the antibodies in question are elicited as a result of exposure to many natural substances possessing widely crossreacting antigens and are not a result of widespread infection of man with replication-competent oncoviruses.
Keywords: *Antibodies, Viral *Antibody Specificity Apoproteins/IMMUNOLOGY Carbohydrates/IMMUNOLOGY Cross Reactions Glycoproteins/*IMMUNOLOGY Haptens Human Retroviridae/*IMMUNOLOGY Sarcoma Viruses, Simian/*IMMUNOLOGY Support, U.S. Gov't, P.H.S. Viral Proteins/*IMMUNOLOGY JOURNAL ARTICLEKWDantibodies,viralKWDantibodyspecificityapoproteins/immunologycarbohydrates/immunologycrossreactionsglycoproteins/KWDimmunologyhaptenshumanretroviridae/KWDimmunologysarcomaviruses,simian/KWDimmunologysupport,uKWDsKWDgov't,pKWDhKWDsKWDviralproteins/KWDimmunologyjournalarticle
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