Chronic rotavirus infection in immunodeficiency.

Important note: Information in this article was accurate in 1980. The state of the art may have changed since the publication date.

Chronic rotavirus infection in immunodeficiency.

J Pediatr. 1980 Jul;97(1):61-5. Unique Identifier : AIDSLINE MED/80206411
Saulsbury FT; Winkelstein JA; Yolken RH

Abstract: The characteristics of rotavirus infection in 23 children with a variety of primary immunodeficiency diseases were studied. Stools and sera were tested for rotavirus by means of the enzyme-linked immunosorbent assay and the enzyme-linked fluorescent assay, respectively. Four immunodeficient patients had diarrhea during the study period and all had rotavirus infection; rotavirus was not detected in the stools of the 19 asymptomatic immunodeficient patients. Forty-six control children with diarrhea were tested and 22 had rotavirus infection; rotavirus was not detected in 39 asymptomatic control children. One immunodeficient patient with X-linked agammaglobulinemia and one with severe combined immunodeficiency had chronic, symptomatic rotavirus infection with rotavirus excretion lasting more than six weeks. The other two immunodeficient patients and eight control children eliminated the rotavirus from their stools in periods ranging from two to 12 days. Rotavirus antigen was detected in the sera of three of the four immunodeficient patients; none of the 14 control infants tested had rotavirus antigen detected in their sera. This study indicates that rotavirus may produce a chronic infection in immunodeficient children.

Keywords: Adolescence Case Report Child Child, Preschool Chronic Disease Comparative Study Diarrhea/*COMPLICATIONS/DIET THERAPY Human Immunologic Deficiency Syndromes/*COMPLICATIONS Infant Male Milk, Human Rotavirus Support, U.S. Gov't, P.H.S. Virus Diseases/*COMPLICATIONS/DIET THERAPY JOURNAL ARTICLE
801030
M80A0001

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