Persistent transfusion-associated infectious mononucleosis with transient acquired immunodeficiency.

Important note: Information in this article was accurate in 1980. The state of the art may have changed since the publication date.

Persistent transfusion-associated infectious mononucleosis with transient acquired immunodeficiency.

Am J Med. 1980 Mar;68(3):437-40. Unique Identifier : AIDSLINE MED/80150937
Purtilo DT; Paquin LA; Sakamoto K; Hutt LM; Yang JP; Sparling S; Beberman N; McAuley RA

Abstract: Trauma and blood transfusion led to profound, persistent infectious mononucleosis in a 21 year old man. Splenectomy and trauma had apparently produced transient immune deficiency which was complicated by osteomyelitis of a fractured tibia. The transfused blood probably contained Epstein-Barr virus (EBV). Infectious mononucleosis had ensued 25 days after a blood transfusion was given, antibodies to EBV appeared in his serum, and the infectious mononucleosis persisted for nearly two years. His immunity returned gradually to normal, but because of nonunion of the fracture site, which was infected by Staphylococcus aureus, above-knee amputation was required. The acquired, transient immune deficiency to EBV and profound infectious mononucleosis seen in this patient is analogous to inherited, permanent immune deficiency to this virus in the X-linked lymphoproliferative syndrome.

Keywords: Adult Antibodies, Viral/IMMUNOLOGY Blood Transfusion/*ADVERSE EFFECTS Case Report Fractures/COMPLICATIONS Herpesvirus 4, Human/IMMUNOLOGY Human Immunologic Deficiency Syndromes/*ETIOLOGY/IMMUNOLOGY Infectious Mononucleosis/*ETIOLOGY/IMMUNOLOGY Male Osteomyelitis/ETIOLOGY Staphylococcal Infections/ETIOLOGY Support, U.S. Gov't, P.H.S. Time Factors JOURNAL ARTICLE $KWDadverseeffectscasereportfractures/complicationsherpesvirus4,human/immunologyhumanimmunologicdeficiencysyndromes/$
800730
M8070002

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