Cytomegalovirus and dual infection in infants. NLM AIDSLINE Important note: Information in this article was accurate in 1980. The state of the art may have changed since the publication date.

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Cytomegalovirus and dual infection in infants.

Arch Neurol. 1980 Apr;37(4):236-8. Unique Identifier : AIDSLINE MED/80152838
Bale JF Jr; Reiley TT; Bray PF; Kelsey DK

Abstract: In four unrelated infants without underlying immunodeficiency, dual infections with cytomegalovirus (CMV) and another microorganism developed. The patients included the following: (1) a 3-month-old girl with congenital CMV and perinatal cutaneous herpes simplex virus; (2) a 5-week-old girl with CMV and Pneumocystis carinii; (3) a 12-week-old girl with CMV and Haemophilus influenzae meningitis; and, (4) a 2 1/2-month-old girl with CMV and Escherichia coli meningitis. In all four cases, the patient's initial symptoms were referable not to CMV, but to the companion infecting organism. The diagnoses of CMV infection were made, respectively, by a high index of clinical suspicion in the first three cases and on the basis of a lucent parenchymal defect on computerized tomographic scan in the fourth patient. These cases provide additional evidence that CMV infection may predispose to secondary infection. We recommend that infants who have signs of infection and evidence of CNS abnormalities have cultures made for CMV. Both human CMV and experimental murine CMV infections have been associated with suppressed cellular and possibly humoral immunity.
Keywords: Case Report Cytomegalovirus Infections/*COMPLICATIONS Escherichia coli Infections/DIAGNOSIS Female Herpes Simplex/DIAGNOSIS Human Hydrocephalus/DIAGNOSIS Infant Infant, Newborn Meningitis/DIAGNOSIS Meningitis, Haemophilus/DIAGNOSIS Pneumonia, Pneumocystis carinii/DIAGNOSIS JOURNAL ARTICLEKWDcasereportcytomegalovirusinfections/
800730
M8070001

Copyright © 1980 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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