Acquired dysfunction due to the circulation of exhausted platelets.

Important note: Information in this article was accurate in 1980. The state of the art may have changed since the publication date.

Acquired dysfunction due to the circulation of exhausted platelets.

Am J Med. 1980 Aug;69(2):235-40. Unique Identifier : AIDSLINE MED/80263073
Pareti FI; Capitanio A; Mannucci L; Ponticelli C; Mannucci PM

Abstract: An acquired platelet functional defect was found to be present in eight patients who presented with various clinical conditions--three with renal allograft rejection, three with the hemolytic uremic syndrome or thrombotic thrombocytopenic purpura, one with acute consumption coagulopathy due to an incompatible transfusion and one with systemic lupus erythematosus. They showed defective platelet aggregation and reduced levels of adenine nucleotides and serotonin with abnormal uptake and storage of the amine. The bleeding time was more prolonged than predicted from the platelet count. These abnormalities were strikingly similar to those occurring in patients with congenital storage pool deficiency. The acquired defect is thought to be related to the presence in the circulation of exhausted platelets following their in vivo exposure to inducers of the release reaction such as damaged endothelium, thrombin and immune complexes. The bleeding tendency of the underlying diseases might be aggravated by the impairment of platelet function.

Keywords: Adenosine Diphosphate/BLOOD Adenosine Triphosphate/BLOOD Adult Antigen-Antibody Complex Blood Platelet Disorders/*ETIOLOGY/IMMUNOLOGY Blood Platelets/METABOLISM/*PHYSIOLOGY Case Report Child Female Graft Rejection Human Immunologic Diseases/BLOOD Male Platelet Aggregation Platelet Function Tests Serotonin/BLOOD JOURNAL ARTICLE
801230
M80C0003

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