The expression pattern of hepatitis B e antigen and antibody in different ethnic and clinical groups of hepatitis B surface antigen carriers. NLM AIDSLINE Important note: Information in this article was accurate in 1980. The state of the art may have changed since the publication date.

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The expression pattern of hepatitis B e antigen and antibody in different ethnic and clinical groups of hepatitis B surface antigen carriers.

J Infect Dis. 1980 Jul;142(1):18-22. Unique Identifier : AIDSLINE MED/80250550
Aldershvile J; Skinhoj P; Frosner GG; Black F; Deinhardt F; Hardt F; Nielsen JO

Abstract: The presence of hepatitis B e antigen (HBeAg) and its antibody (anti-HBe) was studied in 249 asymptomatic carriers of hepatitis B surface antigen (HBsAg) of different ethnic origin and clinical course. Among male homosexuals, renal transplant recipients, and hemodialysis patients, > 90% were HBeAg-positive. In contrast, anti-HBe was present in > 85% of HBsAg-positive Danish pregnant women and blood donors. In presumably immunologically intact persons, significantly elevated levels of transaminases were found in the HBeAg-positive group as compared with the anti-BHe group (P < 0.0001). Among persons with Down's syndrome, males showed a tendency toward clearing of HBeAg and development of anti-BHe as compared with females. In Eskimos a correlation was found between presence of hepatitis B e markers, age of the HBsAg carrier, and geographic origin of the carrier. A similar age relationship was found in Vietnamese refugees. It is proposed that in the general population a correlation may exist between the prevalence of HBsAg carriers and the percentage of HBeAg-positive HBsAg carriers.
Keywords: Adolescence Adult *Antibodies, Viral Carrier State/IMMUNOLOGY Child Down Syndrome/IMMUNOLOGY Eskimos Female Hepatitis B/*EPIDEMIOLOGY *Hepatitis B Antibodies *Hepatitis B Surface Antigens Homosexuality Human Kidney/TRANSPLANTATION Kidney Transplantation Liberia Male Pregnancy Vietnam JOURNAL ARTICLEKWDadolescenceadultKWDantibodies,viralcarrierstate/immunologychilddownsyndrome/immunologyeskimosfemalehepatitisb/KWDepidemiologyKWDhepatitisbantibodiesKWDhepatitisbsurfaceantigenshomosexualityhumankidney/transplantationkidneytransplantationliberiamalepregnancyvietnamjournalarticle
801230
M80C0001

Copyright © 1980 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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