Partial immunologic reconstitution and hyperimmunoglobulinemia-E in neonatally-acquired graft-versus-host disease. NLM AIDSLINE Important note: Information in this article was accurate in 1980. The state of the art may have changed since the publication date.

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Partial immunologic reconstitution and hyperimmunoglobulinemia-E in neonatally-acquired graft-versus-host disease.

Ann Allergy. 1980 Apr;44(4):212-6. Unique Identifier : AIDSLINE MED/80173424
Church JA; Uittenbogaart C

Abstract: A three-month-old girl with congenital immune deficiency developed graft-versus-host disease following engraftment of maternal immunocompetent cells. T and B lymphocyte numbers increased and lymphocyte responsiveness to phytohemagglutinin normalized during the patient's hospitalization. However, these cells failed to respond to pokeweed mitogen and several specific antigens, suggesting that the expanding clone of alloreactive cells had limited immunologic potential. Serum IgE concentration rose from an undetectable level to 2,600 u/ml, indicating an immunoregulatory imbalance. HLA typing revealed that the patient's parents shared HLA antigen specificities. Finally, experimental administration of antithymocyte globulin had no beneficial effect upon the patient's clinical course or laboratory findings.
Keywords: B-Lymphocytes Case Report Erythrocytes/ENZYMOLOGY Female *Graft vs Host Reaction Human Hypergammaglobulinemia/*IMMUNOLOGY HLA Antigens IgE/BIOSYNTHESIS Immunologic Deficiency Syndromes/*CONGENITAL Infant Infant, Newborn Infant, Newborn, Diseases/*IMMUNOLOGY Leukocyte Count Lymphocyte Transformation Phytohemagglutinins/PHARMACOLOGY Pokeweed Mitogens/PHARMACOLOGY T-Lymphocytes JOURNAL ARTICLE

KWDb-lymphocytescasereporterythrocytes/enzymologyfemaleKWDgraftvshostreactionhumanhypergammaglobulinemia/KWDimmunologyhlaantigensige/biosynthesisimmunologicdeficiencysyndromes/KWDcongenitalinfantinfant,newborninfant,newborn,diseases/KWDimmunologyleukocytecountlymphocytetransformationphytohemagglutinins/pharmacologypokeweedmitogens/pharmacologyt-lymphocytesjournalarticle
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Copyright © 1980 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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