Business Wire - December 3, 2008

Summary of the Report

Biological weapons of mass destruction and emerging pandemic threats represent a significant security and health challenge for all nations. The development and commercialization of traditional drug and vaccine countermeasures is an immense challenge requiring enormous resources. The advancement of single-target drug and vaccine therapies as the predominant strategy to address a universe of known and unknown bioterror and pandemic threats is clinically and economically unfeasible. Accordingly, the Department of Health and Human Services (HHS) of the United States has decreed that broad-spectrum therapies, able to demonstrate effectiveness in combating multiple pathogens, will become a focal point for government initiatives that encourage the development of countermeasures against bioterror and pandemic threats. This paper introduces the Aethlon Hemopurifier(R) as the most advanced broad-spectrum treatment platform as evidenced by a breadth of supporting in vitro data and human treatment experience.

About Aethlon Medical

Aethlon Medical is the developer of the Hemopurifier(R), a first-in-class medical device designed to treat infectious disease. The Hemopurifier(R) provides real-time therapeutic filtration of infectious viruses and immunosuppressive particles, and is positioned to address the treatment of drug and vaccine resistant viruses. Additionally, the device holds promise in cancer care, as research studies have verified the Hemopurifier(R) is able to capture immunosuppressive particles secreted by tumors. The Hemopurifier(R) is designed to act both as a stand-alone therapeutic, and as an adjunct treatment to enhance clinical benefit of established therapies. Pre-clinical studies conducted by researchers representing leading government and non-government health organizations both in the United States and abroad have documented the effectiveness of the Hemopurifier(R) in capturing from circulation the viruses that constitute pandemic threats, including H5N1 Avian Influenza (bird flu), and Dengue Hemorrhagic Fever (DHF) from circulation. The company is conducting studies to support the use of the Hemopurifier(R) as a broad-spectrum treatment countermeasure against bioterror threats, including Smallpox, and Ebola, Marburg, and Lassa hemorrhagic fever. Regulatory and commercialization initiatives in the United States are presently focused on bioterror threats, while international initiatives are directed toward naturally evolving pandemic threats, and chronic infectious disease conditions including the Human Immunodeficiency Virus (HIV) and Hepatitis-C (HCV). Aethlon has demonstrated safety of the Hemopurifier(R) in a 24-treatment human study at the Apollo Hospital in Delhi, India, and in an 18-treatment study at the Fortis Hospital, also located in Delhi. The company has submitted an investigational device exemption (IDE) to the U.S. Food and Drug Administration (FDA) to advance the Hemopurifier(R) as a broad-spectrum treatment countermeasure against category "A" bioterror threats. Additional information regarding Aethlon Medical and its Hemopurifier(R) technology is available online at www.aethlonmedical.com.

Certain of the statements herein may be forward-looking and involve risks and uncertainties. Such forward-looking statements involve assumptions, known and unknown risks, uncertainties and other factors which may cause the actual results, performance or achievements of Aethlon Medical, Inc to be materially different from any future results, performance, or achievements expressed or implied by the forward-looking statements. Such potential risks and uncertainties include, without limitation, the Company's ability to raise capital when needed, the Company's ability to complete the development of its planned products, the ability of the Company to obtain FDA and other regulatory approvals permitting the sale of its products, the Company's ability to manufacture its products and provide its services, the impact of government regulations, patent protection on the Company's proprietary technology, product liability exposure, uncertainty of market acceptance, competition, technological change, and other risk factors. In such instances, actual results could differ materially as a result of a variety of factors, including the risks associated with the effect of changing economic conditions and other risk factors detailed in the Company's Securities and Exchange Commission filings.

Contacts

Aethlon Medical, Inc. | Jeff Richardson | Senior Director, Communications | 858-459-7800 x302 | jrichardson@aethlonmedical.com

or

Jim Frakes | Senior VP Finance | 858-459-7800 x300 | jfrakes@aethlonmedical.com

or

James A. Joyce | Chairman, CEO | 858-459-7800 x301 | jj@aethlonmedical.com

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