ChromaVision Collaborates With UCLA on Advanced HIV Diagnostic Test Business Wire
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ChromaVision Collaborates With UCLA on Advanced HIV Diagnostic Test

Business Wire - November 15, 1999


SAN JUAN CAPISTRANO, Calif.--(BUSINESS WIRE)--Nov. 15, 1999-- ChromaVision Medical Systems Inc. (Nasdaq:CVSN), developer of unique cellular imaging diagnostics and manufacturer of the Automated Cellular Imaging System (ACIS)(TM), Monday announced a collaboration with the University of California, Los Angeles, School of Medicine to enter into feasibility studies to validate a new ACIS-based test to detect and quantify the total Human Immunodeficiency Virus (HIV) reservoir in the peripheral blood cells of HIV-infected persons.

UCLA School of Medicine virologist and recognized expert in HIV, Kathie Grovit-Ferbas, Ph.D., will lead the validation studies. The ACIS viral load test, performed using the immunohistochemical (IHC) staining method, may improve detection of HIV and provide more meaningful information for treatment decisions and disease management.

A new study performed by researchers at Thomas Jefferson University in Philadelphia and published in the Journal of the American Medical Association on Nov. 3, 1999, reported that even though current drug therapies can suppress HIV in the bloodstream to nearly undetectable levels, the virus can continue to reproduce within the cell. Eighty thousand new cases of HIV are diagnosed each year in the United States alone.

Grovit-Ferbas received a Ph.D. from the Department of Infectious Diseases and Microbiology at the University of Pittsburgh and has focused her career largely on HIV. She has authored numerous scientific papers relating to HIV and is a member of the UCLA AIDS Institute, directed by Irvin S.Y. Chen, Ph.D.

Referring to the current UCLA collaboration with ChromaVision, Grovit-Ferbas said: "The detection of total viral reservoir at the cellular level may prove to be extremely valuable in HIV disease management. In addition, the ACIS could be a very useful tool in ongoing research aimed at developing more effective therapies for this disease."

ChromaVision CEO and President Dr. Douglas S. Harrington stated: "As with all infectious diseases, it is critical to detect HIV reservoirs with the most sensitive and accurate means possible. Using currently available IHC staining methods, ACIS has the potential to allow the pathologist or laboratory technician to quantify accurately the number of virus infected cells, providing important information to both the doctor and patient."

"In parallel with the HIV study, UCLA will be evaluating the use of the ACIS in a related infection that occurs in patients with suppressed or deficient immune systems known as Cytomegalovirus (CMV)," continued Harrington.

"CMV is an aggressive virus that affects such immunocompromised individuals as transplant recipients and AIDS patients. This virus often causes blindness or death, and is difficult to detect using conventional means."

About ChromaVision Medical Systems

ChromaVision Medical Systems manufactures and markets an advanced cellular imaging system designed to advance the detection, diagnosis and treatment of cellular disease.

The Automated Cellular Imaging System (ACIS)(TM) combines proprietary, color-based imaging technology with automated microscopy to bring unprecedented sensitivity, accuracy and reproducibility to cancer, infectious disease and genetic cell-based diagnostics.

ChromaVision currently markets its products to physicians and researchers in university medical centers and commercial laboratories throughout the world.

ChromaVision Medical Systems Inc. (Nasdaq:CVSN) was formed by XL Vision Inc., and is a Safeguard Scientifics Inc. (NYSE:SFE) partnership company.

For more information on ChromaVision Medical Systems, visit the company's Web site at http://www.chromavision.com.

The statements contained herein regarding ChromaVision Medical Systems Inc. contain forward-looking statements that involve risks and uncertainty. Future events and the company's actual results could differ materially from the results reflected in these forward-looking statements. Factors that might cause such a difference include, but are not limited to, uncertainty of success in developing any new diagnostic test, failure to obtain FDA clearance or approval for particular applications and dependence on third parties for clinical testing. ACIS is a trademark of ChromaVision Medical Systems Inc.

CONTACT: ChromaVision Medical Systems Inc., San Juan Capistrano Kevin C. O'Boyle or Patricia Sisson, 888/443-3310 or Allen & Caron Inc. Matt Clawson (investors), 714/957-8440
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